O-Acetyltransferases for chloramphenicol and other natural products.
نویسندگان
چکیده
منابع مشابه
Simultaneous Chloramphenicol and Florfenicol Determination by A Validated DLLME-HPLC-UV Method in Pasteurized Milk
The antibiotic residues in milk are a well-known serious problem and pose several health hazards to consumers. We have described a simple, rapid, and inexpensive DLLME-HPLC/UV technique for the extraction of chloramphenicol and florfenicol residues in milk samples. Under the optimum conditions, linearity of the method was observed over the range 0.02-0.85 µg/L with correlation coefficients > 0....
متن کاملReaction products of chloramphenicol acetyltransferases from enterobacteria and Haemophilus influenzae.
The reaction products of Types I, II and III chloramphenicol acetyltransferases (CATs) from reference strains of Escherichia coli and Type II CATs from clinical isolates of Haemophilus influenzae were examined by HPLC. Types I and III CATs produced 1, 3 diacetylchloramphenicol at pH 6.8 and 7.8 whereas Type II enzymes failed to produce this diester at either pH. All the CATs produced monoacetyl...
متن کاملSimultaneous Chloramphenicol and Florfenicol Determination by A Validated DLLME-HPLC-UV Method in Pasteurized Milk
The antibiotic residues in milk are a well-known serious problem and pose several health hazards to consumers. We have described a simple, rapid, and inexpensive DLLME-HPLC/UV technique for the extraction of chloramphenicol and florfenicol residues in milk samples. Under the optimum conditions, linearity of the method was observed over the range 0.02-0.85 µg/L with correlation coefficients > 0....
متن کاملIdentification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri.
The 16.5-kbp plasmid pSCFS1 from Staphylococcus sciuri mediated combined resistance to chloramphenicol and florfenicol. The gene responsible for this resistance property, cfr, was cloned and sequenced. The amino acid sequence of the Cfr protein revealed no homology to known acetyltransferases or efflux proteins involved in chloramphenicol and/or florfenicol resistance or to other proteins whose...
متن کاملUnusual acylation of chloramphenicol in Lysobacter enzymogenes, a biocontrol agent with intrinsic resistance to multiple antibiotics
BACKGROUND The environmental gliding bacteria Lysobacter are emerging as a new group of biocontrol agents due to their prolific production of lytic enzymes and potent antibiotic natural products. These bacteria are intrinsically resistant to many antibiotics, but the mechanisms behind the antibiotic resistance have not been investigated. RESULTS Previously, we have used chloramphenicol acetyl...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 41 1 شماره
صفحات -
تاریخ انتشار 1997